Ivermectin, Fenbendazole and Mebendazole for Stage 4 Pancreatic Cancer: 21 Case Reports Compilation (2025)
Fenbendazole and ivermectin show promise in stage 4 pancreatic cancer
Abstract
Background: Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, with limited effective therapies and poor survival, especially in stage 4 disease. Repurposing antiparasitic agents such as fenbendazole and ivermectin has garnered interest due to their demonstrated anti-cancer properties in preclinical studies.
Methods: We reviewed and synthesized 21 case reports from 2022 to 2025 documenting the clinical use of fenbendazole and ivermectin, alone or in combination with standard therapies, in patients with advanced pancreatic cancer. Tumor markers, imaging outcomes, and clinical responses were analyzed alongside mechanistic literature.
Results: Across cases, patients exhibited marked reductions in CA19-9 tumor markers (often >70%), significant tumor shrinkage on imaging, and improved clinical status. Responses were observed even in chemotherapy-resistant and metastatic disease. Mechanistic studies support multiple anti-cancer effects of these agents, including apoptosis induction, inhibition of cancer stem cells, reversal of multidrug resistance, and sensitization to chemotherapy and radiation.
Conclusion: Fenbendazole and ivermectin show promise as adjunctive therapies in stage 4 pancreatic cancer. Despite encouraging case-based evidence, controlled clinical trials are urgently needed to validate efficacy and safety.
Introduction
Pancreatic cancer is the seventh leading cause of cancer-related death worldwide, with a 5-year survival rate below 10% . Pancreatic ductal adenocarcinoma (PDAC) constitutes approximately 80% of cases and is characterized by late presentation, aggressive biology, and resistance to conventional therapies . Over 90% of PDACs harbor activating mutations in KRAS, contributing to therapeutic challenges .
Standard treatments including surgical resection, chemotherapy (e.g., FOLFIRINOX, gemcitabine-based regimens), and radiation offer limited survival benefits, particularly in metastatic (stage 4) disease where median survival is 3–6 months . Novel approaches are urgently needed.
Drug repurposing offers a cost-effective strategy to identify new cancer therapies. Fenbendazole, a benzimidazole anthelmintic used in veterinary medicine, and ivermectin, an FDA-approved antiparasitic for humans, have demonstrated anti-cancer effects in vitro and in vivo [5–7]. These include microtubule disruption, apoptosis induction, inhibition of cancer stem cells, and reversal of multidrug resistance.
This manuscript compiles and analyses 21 case reports [10] of fenbendazole and ivermectin use in stage 4 pancreatic cancer, highlighting clinical outcomes and underlying mechanisms.
Case Presentations
Case No. 21 - 2025: 60 year old Arizona man with Stage 4 Pancreatic Cancer
Dr William Makis shared on X.com in November 2025:
IVERMECTIN and FENBENDAZOLE Testimonial - 60 year old Arizona man with Stage 4 Pancreatic Cancer reports after 4 months. There is nothing more uplifting than a happy email from a cancer patient.
60 year old Arizona man with Stage 4 Pancreatic Cancer with liver and bone metastases In mid June 2025 he started:
Ivermectin 60mg/day
Fenbendazole 1000mg/day
(Oncologist: modified FOLFIRINOX from May 19)
Results after 4 months:
Pancreatic Mass shrunk: 11.9cm to 8.3cm
Liver metastases shrunk
Lymph node metastases shrunk
CA19-9 dropped 7960 to 2058.
Sometimes we run into the issue of confusing imaging results, where everything is improving and one spot seems to be “worse”. This happens especially with bone metastases as a healing bone metastasis will often appear larger and more sclerotic on a CT scan. I’m not a fan of trigger happy Radiation Oncologists who want to irradiate everything even if there is no pain.
Case No. 20 - 2025: 67 year old Minnesota man with Stage 4 Pancreatic Cancer
Dr William Makis shared on X.com in November 2025:
IVERMECTIN and MEBENDAZOLE Testimonial - 67 year old Minnesota man with Stage 4 Pancreatic Cancer reports after 5 months.
This cancer patient relied on mainstream Oncology as his Pancreatic Cancer went from Stage 1 to Stage 4 within 2 years. Then he came to me and thank God he did. 67 year old Minnesota man with Stage 4 Pancreatic Cancer April 2023 - 2.2cm head of pancreas mass diagnosed Jan 2024 - Whipple procedure Feb 2025 - 1.5cm liver metastasis detected (Stage 4) By the miracle of modern Oncology, he went from Stage 1 to Stage 4 in less than 2 years! Incredible! In late March 2025 he started: Ivermectin 1.5mg/kg/day
Mebendazole 1000mg/day (Oncologist put him on chemo) Results after 6 months:
CA19-9 580 (Feb) to 250 (May) to 82 (Jul)
October 2025 SIGNATERA = 0
1.5cm Liver metastasis resolved
He is currently considered “Cancer Free”.
Case No. 19 - 2025: 67 year old Michigan woman with Stage 4 Pancreatic Cancer post Whipple
Dr William Makis shared on X.com in November 2025:
MEBENDAZOLE Testimonial - 67 year old Michigan woman with Stage 4 Pancreatic Cancer post Whipple reports after 2 months
It’s rare that I have testimonials and success stories from the use of just one repurposed drug but it does happen! STORY 67 year old Michigan woman with Stage 4 Pancreatic Cancer post Whipple In mid August 2025, she started:
Mebendazole 1500mg/day
Results after 2 months:
CA19-9 800s to 80s
Pancreatic and Liver tumors shrunk by 50%
Case No. 18 - 2025: 64 year old Ontario man with Stage 4 Pancreatic Cancer to liver
Ivermectin and Fenbendazole Testimonial - 64 year old Ontario man with Stage 4 Pancreatic Cancer to liver has incredible response after 2 months, CA19-9 down 93%.
Source: Dr William Makis shared on Substack in August 2025.
Case No. 17 - 2025: 57 year old South Korean man with Stage 4 Pancreatic Cancer metastatic to the liver
Source: Dr William Makis shared on X.com in August 2025:
Ivermectin and Fenbendazole Testimonial - 57 year old South Korean man with Stage 4 Pancreatic Cancer metastatic to the liver reports after one month 57 year old South Korean man with Stage 4 Pancreatic Cancer metastatic to the liver We started on April 16, 2025:
Ivermectin 24mg increasing to 72mg/day
Fenbendazole 444mg increasing to 1556mg/day
Oncologist started FOLFIRINOX Chemo on March 24, 2025
Results after 1 month:
Pancreatic mass 5.0cm to 4.2cm = 40.7% tumor volume shrinkage.
CA19-9 2067 to 438 = 79% drop.
The combination of Ivermectin, Fenbendazole and chemo can yield very powerful results!
Case No. 16 - 2025: Canadian with stage 4 pancreatic cancer who was offered euthanasia
A patient with stage 4 pancreatic cancer who was offered euthanasia (Medical Assistance in Dying, MAID) is cancer-free a few months later.
A Canadian patient developed pancreatic cancer 6 months after receiving a COVID vaccine.
He had surgery to remove it, but 15 months later, CT scans showed a recurrence of stage 4 pancreatic cancer, including metastases to the lungs.
This patient with stage 4 pancreatic cancer was offered typical Canadian cancer care:
“I was immediately visited by social workers to discuss end of life and MAID (medical assistance in dying or euthanasia).
In addition to palliative chemotherapy, Dr. Makis’ treatment was:
Fenbendazole 444 mg/day for at least 3 months
Fenbendazole 444 mg/day with liquid ivermectin (1 teaspoon) = 50 mg for 2 months.
Results:
“The CT scan showed that all signs of cancer were undetectable and essentially resolved.”
In Dr. Makis’s clinical experience, pancreatic cancer responds very well to the combination of ivermectin and fenbendazole.
Ivermectin kills cancer cells that chemotherapy fails to kill. Ivermectin also reverses multidrug resistance (chemo resistance).
The patient’s primary oncologist was shocked by the sudden turnaround, but most importantly, this patient managed to avoid Canada’s first approach to cancer care: euthanasia.
Source: https://x.com/MakisMD/status/1877991419777831412 (Jan 2025)
Case No. 15 - 2025: 66 year old Netherlands Man with Stage 4 Pancreatic Cancer with a solitary liver metastasis
Dr William Makis shared on X (Twitter) in June 2025:
IVERMECTIN and FENBENDAZOLE Testimonial - 66 year old Netherlands Man with Stage 4 Pancreatic Cancer with a solitary liver metastasis. In 4 months, it shrunk by 99.7%! Shocking story! There is an extremely important lesson here! I absolutely love this Pancreatic Cancer success story.
66 year old Netherlands man was diagnosed with Stage 4 Pancreatic Cancer in Oct.2024 with a solitary liver metastasis.
On January 31 2025 we started:
Ivermectin 1mg/kg/day
Fenbendazole 888mg/day (briefly increased to 1776mg/day then 1332mg/day but he went back down to 888mg/day)
Feb.19, 2025 Oncologist started FOLFIRINOX Chemo
After 5 weeks (Mar.7) lesion INCREASED 34.7mm to 40.1mm
After 10 weeks (Apr.11) lesion DECREASED from 40.1mm to 35.8mm
After 4 months (Jun.3) lesion DECREASED from 35.8mm to 11.1mm (99.7% volume shrinkage!!)
What’s very interesting in this case is that the liver lesion got mildly larger after 5 weeks, before it started shrinking. The other possibility is that it remained unchanged in size as we were comparing CT (34.7mm) to MRI (40.1mm) measurements, which are different imaging modalities. Regardless, the liver lesion didn’t improve for at least 5 weeks!
However, by the end of 4 months, the lesion had shrunk by 99.7% in tumor volume!! This is WHY you don’t quit after 1 month!
Case No. 14 - 2025: 67 year old Maryland woman was diagnosed with a Pancreatic Cancer 2.3cm, failed 3 months of chemo with Stage 4 spread to the liver
Dr William Makis shared on X (Twitter) in June 2025:
IVERMECTIN and FENBENDAZOLE Testimonial - 67 year old Maryland woman was diagnosed with a Pancreatic Cancer 2.3cm, failed 3 months of chemo with Stage 4 spread to the liver.
She is now Cancer Free! From Stage 4 Pancreatic Cancer to CANCER FREE in 2.5 months!
Due to recent attacks, I will be posting even more testimonials STORY: 67 year old Maryland woman was diagnosed with Pancreatic Cancer, a 2.3x2.2cm Pancreatic Head Mass
She had 3 months of neoadjuvant chemotherapy with FOLFIRINOX from Sep.30, 2025 to Jan.2025 but MRI done Jan.7, 2025 showed no improvement and a suspicion of progression to Stage 4 with new liver metastases. After failing chemo, this patient reached out to me.
In early March 2025 we started:
Ivermectin 1.5mg/kg/day
Fenbendazole 1000mg/day
CBD Oil 100mg/day
RESULTS after 2.5 months: CT May 20, 2025:
“Previous mass pancreatic head is no longer visualized”
“Images of the liver…previous small enhancing nodules are not seen”
CA19-9 also dropped from 942 to 9. My Take… Big Pharma shills will always say that it was the chemo that did all the work in these cases and that Ivermectin and Fenbendazole didn’t do anything.
Here you have a case of a 67 year old woman with a 2.3cm Pancreatic Head Cancer who didn’t respond at all to FOLFIRINOX chemo and instead progressed to Stage 4 with liver metastases. Add Ivermectin and Fenbendazole and 2.5 months later, both the Pancreatic mass and liver lesions are GONE. The patient is currently CANCER FREE!
"Hi Dr.Makis, enclosed is the latest scan and it's outstanding. Thank you and your team for everything. You are a God send".
Case No. 13 - 2025: 78 year old California man with poorly differentiated Stage 4 Neuroendocrine Pancreatic Cancer
Dr William Makis shared on X (Twitter) in June 2025:
IVERMECTIN and FENBENDAZOLE Testimonial - 78 year old California man with poorly differentiated Stage 4 Neuroendocrine Pancreatic Cancer had a dramatic response after 3 months!
Poorly Differentiated Neuroendocrine cancers are considered almost impossible to treat, by mainstream Oncology.
STORY: 78 year old California man was diagnosed with Stage 4 NEUROENDOCRINE Pancreatic Cancer (10cm mass) metastatic to the liver
We started:
Ivermectin 1.0mg/kg/day
Fenbendazole 1500mg/day
CBD Oil 100mg/day
RESULTS: after 3 months (PET May 2, 2025)
Pancreatic Mass 10.4x8.2x6.2cm to 8.3x2.4cm = 77% tumor volume reduction of primary tumor
Liver metastasis 4.6x4.4cm to 1.4x1.3cm = 97.3% tumor volume reduction
Liver metastasis 4.3x3.7cm to 2.7x2.2cm = 77.8% tumor volume reduction
Left adrenal metastasis 3.1cm to 2.1cm = 68.9% tumor volume reduction
Upper abdominal lymph node 8mm resolved = 100% tumor volume reduction
The synergy between Ivermectin, Fenbendazole and chemotherapy is giving results that often shock the Oncologists.
From the patient's family:
"he seems to be responding exceptionally well to treatment"
And it's nice when patients recognize the efforts undertaken to get them these kinds of results.
"I wanted to first of all extend a huge thank you to you for your help with my dad's case. And also for your continued determination and courage with your research and patient care"
"I realize you have come under a lot of fire and I admire and commend your willingness to speak out and to continue fighting against the corruption."
"We need more expert voices like you in this world!"
Case No. 12 - 2025: 66 year old man with Stage 4 Inoperable Pancreatic Cancer on 3rd line chemo and growing pancreatic mass
Dr William Makis shared on X (Twitter) in May 2025:
IVERMECTIN and MEBENDAZOLE Testimonial - 66 year old man with Stage 4 Inoperable Pancreatic Cancer on 3rd line chemo and growing pancreatic mass - gets cancer under control with tumor shrinkage! As the Big Pharma attacks escalate, I will post even more Cancer Success stories! No one ever talks about chemotherapy failure rates, I wonder why that is. Most of the cancer patients who come to me from around the world are failing chemo after chemo after chemo after chemo...
STORY: 66 year old man with inoperable Stage 4 Pancreatic Cancer had been on: mFOLFIRINOX from Oct.2023 to May 2024
Gemcitabine/Abraxane from May 2024
Added Cisplatin June 2024 due to increasing CA19-9
Switched Cisplatin to Oxaliplatin Feb.2025 due to increasing CA19-9
His Oncologists call this two lines of chemotherapy but I count four...all failed...but I digress... Patient came to me in January 2025 with a growing pancreatic mass: "Gemcitabine and cisplatin and abraxane which brought numbers down and stable tumor but now that has worn off - tumor in pancreas growing and number getting larger CA19-9." Chemo seems to fail so often, doesn't it?
We started early February 2025:
Ivermectin 1.5mg/kg/day
Mebendazole 1500mg/day
RESULTS:
"Numbers came immediately down"
"Scan much better after 2 months - oncologist relayed they don't often see "decrease" in tumor size at his stage"
There's a lot these inept Oncologists don't see. After only 2 months of Ivermectin and Mebendazole:
CA19-9 dropped from 146 to 9.5
Pancreatic mass shrunk from 2.8x1.9cm to 2.8x1.5cm (21% volume shrinkage)
Ideally this patient would have had a PET/CT scan that could have shown us a significant drop in metabolism of the tumor. Whenever you see Ivermectin and Mebendazole attacked, it’s important to understand that these patients are PROGRESSING on chemo after chemo after chemo. And these failing chemos are the BEST that modern medicine has to offer. To get control of a Stage 4 Pancreatic Cancer like this after so many attempts at chemotherapy, is nothing short of a miracle.
Case No. 11 - 2025: 63-year-old woman in Philippines with Stage 4 Pancreatic Cancer
Dr William Makis shared on X (Twitter) in May 2025:
IVERMECTIN and FENBENDAZOLE Testimonial - 63 year old woman in Philippines with Stage 4 Pancreatic Cancer sees 80% tumor shrinkage after 1 month! This is a beautiful international cancer success story! (and a reminder you won't find these successes anywhere else) When you run the world's largest Ivermectin Cancer Clinic, patients come to you from around the world.
STORY: 63 year old woman in the Philippines had recently progressed to Stage 4 Pancreatic Cancer with liver metastases. We started in mid February 2025:
Ivermectin 1.5mg/kg/day
Fenbendazole 1500mg/day
RESULTS after 1 month:
Pancreatic mass shrunk from 5.3x5.4x5.5cm to 3.6x3.1x2.7cm = 81% TUMOR VOLUME SHRINKAGE.
Fascinatingly, CEA went from 36 to 107 to 32.8 during this time. Possible explanation: rapid cancer cell killing caused CEA to rise temporarily.
From the patient:
"We have an exciting update!...a HUGE improvement on her pancreatic tumor size"
"We're so excited by the reduction in her tumor size! Nothing short of a miracle! But CEA seems to have increased which we are confused about? Why is this so?"
"We just received our latest CEA labs...good news!" CEA Tests: 1. Jan.2025 - 36 2. Mar.2025 - 107 3. Apr.2025 - 32.77
"God bless you always Dr.William Makis!!"
I love my cancer patients. Aren't they the best? So this was 1 month on gemcitabine + paclitaxel + Ivermectin (96mg) + Fenbendazole 1554mg.
Case No. 10: 46 year old USA man with Stage 4 Pancreatic Cancer
Dr William Makis shared on X (Twitter) in May 2025:
Ivermectin and Fenbendazole Testimonial - 46 year old USA man with Stage 4 Pancreatic Cancer sees dramatic improvement after 2 months! How about a Pancreatic cancer success story? (Don't tell the Oncologist)
STORY: 46 year old USA man was diagnosed with Stage 4 Pancreatic Cancer metastatic to liver and lungs, in Oct.2024 CT showed a 2.8cm pancreatic mass with innumerable lung nodules, and metastatic disease in the liver up to 7.9cm In early February 2025 we started:
Ivermectin 1.5mg/kg/day
Fenbendazole 2000mg/day
RESULTS after 2 months:
CA19-9 cancer marker drop from 138 to 40.6. CT:
“Overall decreased size of the pulmonary and hepatic metastases”
“Pancreatic mass with peripancreatic lymph node is slightly decreased” “decreased now trace pelvic ascites”
I always get asked about ascites - yes, Ivermectin and Fenbendazole can reduce and eventually eliminate ascites!
From the patient:
"I just received the following response from my oncologist: "Congrats! The Cancer treatment is working and the cancer is shrinking"
I have been helping Oncologists pat themselves on the back for success they didn't earn, ever since I started my Ivermectin Cancer Clinic one year ago. They sure get excited about the amazing results, but have no idea that Ivermectin, Fenbendazole and Mebendazole are doing the heavy lifting!
"Stage 4 Pancreatic cancer is curable. I will prove it." - Dr William Makis
Case No. 9: 46 year-old-male with Stage 4 Pancreatic Cancer
Dr William Makis shared on X (Twitter) in April 2025:
IVERMECTIN and FENBENDAZOLE Testimonial - Stage 4 Pancreatic Cancer post Moderna mRNA Vaccines - 46 year old USA patient improves dramatically after only 2 months! All tumors and metastases shrink! This family has two incredible Pancreatic Cancer success stories from my Ivermectin Cancer Clinic!
STORY: 46 year old man (USA) was diagnosed with Stage 4 Pancreatic Cancer metastatic to lymph nodes, liver and bones. He had two Moderna COVID-19 mRNA Vaccines in 2021. (Possible Turbo Cancer) Oncologist started Folfirinox and Gemcitabine
We started the Makis Ivermectin Cancer Clinic Protocol:
Ivermectin 1.5mg/kg/day
Fenbendazole 1500mg/day
A follow-up PET/CT was done after 2 months on Ivermectin Protocol RESULTS: After 2 months on Ivermectin and Fenbendazole:
Pancreatic head mass shrunk by 21% with 56% drop in metabolism
Lymph node metastases improved or resolved
Liver metastases reduced by 40-45% in number.
Bone metastases improved or resolved.
You never see this kind of response with just chemo. In only 2 months!! This patient was referred by a family friend:
"Hi Dr.Makis...just want to let you know that my uncle who has been on your Protocol since September 1st has seen drastic improvement, his most recent scan showed the tumor in his pancreas has shrunk. This is something the oncologists said was nearly impossible.
However, the main reason for my email is to try and help a family friend with HIS cancer...he has stage 4 pancreatic cancer which has spread to many other organs, his situation is somewhat dire".
That's the case described here with the pancreatic mass and all metastases shrinking after 2 months on Ivermectin and Fenbendazole.
Case No. 8: 53 year-old-male with Stage 4 Pancreatic Cancer
Dr William Makis shared on X (Twitter) in April 2025:
IVERMECTIN and FENBENDAZOLE Testimonial - 53 year old man with Stage 4 Pancreatic Cancer reports back after first 3 weeks...
53 year old man with a new diagnosis of Stage 4 Pancreatic Cancer (metastatic to liver) and rising CA19-9. Got started on 120mg Ivermectin and 1332mg Fenbendazole as soon as possible. CA 19-9 dropped 43% from 154 to 87 after 3 weeks!!
From the patient:
"He began full 120mg Ivermectin + 1332mg Fenbendozole et al approx. March 25. So in about 3 weeks from start of full Makis protocol, BIG DROP in CA 19-9 and Liver ALT went normal too!!!
Even though Liver Mets and legions seen few weeks ago on MRI scan. Everything appears to be clearing rapidly! Anxiously awaiting next scans to see if tumors/legions shrinking but I wanted to reach out and thank you for your tireless efforts!!!
You are making a HUGE difference in the world!!!"
Case No. 7: 77 year old Stage 4 Pancreatic Cancer
Dr William Makis shared on X (Twitter) in April 2025:
FENBENDAZOLE and MEBENDAZOLE Testimonial - 77 year old Stage 4 Pancreatic Cancer patient sees 99.9% drop in CA19-9 levels and shrinkage of tumors by 70 to 87%!
Another incredible Stage 4 Pancreatic Cancer success story! This one may surprise you because Ivermectin was not involved.
77 year old Stage 4 Pancreatic Cancer patient started taking a regimen of Mebendazole and Fenbendazole.
1000mg Mebendazole in the morning
888mg Fenbendazole in the afternoon
RESULTS:
- CA19-9 dropped from 44960 to 21 (99.9% drop)
- small liver lesions resolved - large liver lesion shrunk from 3.6cm to 2.4cm (70% tumor volume decrease)
- 2nd liver lesion shrunk from 2.4cm to 1.2cm (87% tumor volume decrease)
"His Doctors are amazed. His main oncologist told him in 35 years he does not remember a person with results like this. He went as far as calling the results a miracle."
" Dr. Makis, you have saved countless lives with your message, you are the epitome of what health care should be. Thank you"
Very nice to see a Stage 4 Pancreatic Cancer testimonial using Fenbendazole and Mebendazole!
Case No. 6: Stage 4 Pancreatic Cancer
Dr George Fareed shared on X/Twitter (January 2025):
"Patient with stage 4 pancreatic cancer today txted: Great news. Tumor is much smaller than before. 5.4cm to 3.3 cm. I’ve gained about 12 lbs. He continued IVM/mebendazole protocol started 10/24 as well as chemo started 11/24."
Case No. 5: 40s-yr-old male with Stage 4 Pancreatic Cancer (December 2024)
Case shared by Dr William Makis (X/Twitter):
IVERMECTIN and FENBENDAZOLE Testimonial - 40s year old man with Stage 4 Pancreatic Cancer post 2x Pfizer mRNA Vaccines, sees 91% drop in CA19-9* in 2 months! Possible case of Turbo Cancer post 2 Pfizer COVID-19 mRNA Vaccines 40s year old man diagnosed with Pancreatic cancer in 2022 post 2 Pfizer COVID-19 mRNA Vaccines. Had Whipple procedure, then 12 cycles of chemo and 2 months of radiation. Treatments ended May 2023.
Recurrence in June 2024 (mass encasing SMA & liver lesions) Restarted chemo in July 2024 but chemo wasn't working. CA19-9 was skyrocketing. I was consulted in October 2024. We immediately started high dose Ivermectin (up to 2mg/kg/day) and high dose Fenbendazole (up to 888mg/day) 2 months later: (you can read the email for yourself) 91% drop in CA19-9 cancer blood markers! 28340 to 2699. This is my favorite part, seeing results like this, especially when chemo was failing. It's worth persevering on high doses of Ivermectin, Fenbendazole or Mebendazole, and i know it isn't always easy. We struggle with this sometimes.
*Note on pancreatic cancer marker (CA 19-9):
A CA 19-9 test measures the amount of a protein called CA 19-9 (cancer antigen 19-9) in a sample of your blood. CA 19-9 is a type of tumor marker. Tumor markers are substances made by cancer cells or by normal cells in response to cancer in your body. Healthy people can have small amounts of CA 19-9 in their blood. High levels of CA 19-9 are often a sign of pancreatic cancer. But high levels can also be a sign of other types of cancer or certain conditions that aren't cancer. For example, gallstones, pancreatitis and cirrhosis of the liver can cause high CA 19-9 levels.
Case No. 4: Male with terminal Stage 4 pancreatic cancer (October 2024)
Posted by Dave on X.com:
My dad is still alive today 2.5 years after a terminal stage 4 pancreatic cancer diagnosis thanks to MEBENDAZOLE. His pancreatic tumor has been undetectable for 2 years.
Note: Although technically mebendazole is not the same as fenbendazole, both mebendazole and fenbendazole are part of a larger group of drugs known as benzimidazole*, which are anthelmintic drugs (i.e., drugs that kill parasitic worms).
*The class of drugs known as benzimidazoles includes fenbendazole, mebendazole, albendazole and flubendazole.
Fenbendazole and mebendazole are similar in that they both eliminate parasitic worms, but there is a difference. Mebendazole is approved for human consumption by the FDA, while fenbendazole is only approved for veterinary use and has not been approved for human use.
Mebendazole is the form that is approved for human use while fenbendazole is approved for veterinary use. The main difference is the cost. While most of the pre-clinical research uses mebendazole, probably because it is the FDA-approved-for-humans form of fenbendazole, virtually most of the self-treating clinical reports involve the use of fenbendazole.
Case No. 3: Stage 4 Pancreatic Cancer with Liver metastasis - December, 2022
I’m in Remission!! Pancan stage 4 to liver. 5 months JTP 4 months of that 5 with Chemo biweekly. Check out my scan images.(The black areas on 2nd image are my kidneys). I’m getting last chemo infusion today then going on maintenance pills. God Bless Joe Tippens, God, all the prayer warriors. Never give up yall !!
You'r welcome to share my story anywhere and everywhere. I feel I was saved so that I can be a testament to the protocol and share it as much as I can.
Case No. 2 - 2024: Stage 4 Pancreatic Cancer
“My Cancer Story! I was diagnosed with stage 4 pancreatic cancer in August 2023, and without treatment, I had 3-6 months to sort out my affairs.
I began my fenbendazole protocol immediately.
I nearly quit up since my quality of life had deteriorated dramatically. But I started to feel better. Less nausea. I had gained some weight back! Increased energy. My scan in November 2023 indicated that this severe cancer had neither grown or spread. My cancer marker dropped from over 100,000 to 35,000. As of January 2024, my new marker number was 18k!!! My oncologist was just scratching his head, and a family member said he seemed bewildered! And no, I did not inform him about the fenben.”
I was terrified he’d drop me as a patient. I was quite appreciative for fenben and how it has helped me. I was feeling better and stronger. I had scans and bloodwork done in March, and my markers are now down to 6000. And the tumors were shrinking!!! Two weeks after my previous scan. I scanned again, and it returned NED.
This was my protocol:
Morning
Curcumin (600mg daily)
Zinc (50mg)
Milk thistle, As a food supplement, take 15 – 30 drops, 2-3 times daily in a little fruit juice or water. 7 days a week
Serrapeptase (120,00IU)
Fenbendazole (1000mg of Panacur C is advised to be taken seven days a week. It is recommended that it should be taken with a meal).
Night
Curcumin (600mg tablet per day are recommended
Berberine (600mg 2-3 times a day )
Quercetin (500mg 1/day)
Turkey Tail
Vitamin E (800mg for 7 days a week)
Fenbendazole (1000mg at night)
Ivermectin 12mg daily 5/7days a week
Limit sugar and processed food intake
Drank green tea often”
*My Take…
This is an excellent protocol.
*Dr. William Makis is a Canadian physician with expertise in Radiology, Oncology and Immunology. Governor General’s Medal, University of Toronto Scholar. Author of 100+ peer-reviewed medical publications.
**Note on pancreatic cancer marker (CA 19-9):
A CA 19-9 test measures the amount of a protein called CA 19-9 (cancer antigen 19-9) in a sample of your blood. CA 19-9 is a type of tumor marker. Tumor markers are substances made by cancer cells or by normal cells in response to cancer in your body. Healthy people can have small amounts of CA 19-9 in their blood. High levels of CA 19-9 are often a sign of pancreatic cancer. But high levels can also be a sign of other types of cancer or certain conditions that aren't cancer. For example, gallstones, pancreatitis and cirrhosis of the liver can cause high CA 19-9 levels.
Source: COVID Intel (June 2024)
Case No. 1 - 2023: Stage 4 Pancreatic Cancer (Last update: March, 2023)
My family member was diagnosed in stage 4 pancreatic cancer in August 2022. She was told it was very aggressive and without treatment she had 3-6 months and to get her affairs in order. She started 220 fenben immediately. She was very ill and hospitalized with sepsis and colitis from eating tainted peanut butter. She lost about 20 pounds. It took 2 months to start chemo, which made her very sick. We almost gave up because her quality of life had declined significantly. But she started feeling better. Less nausea. She has gained weight back! More energy.. Her latest scan showed this aggressive cancer has not grown or spread. Her cancer numbers or markers went from being over 100k down to 35k.
*** UPDATE: As of today, march 2nd, her new marker number is 18k!!) Her oncologist was just scratching his head.. my family member stated he looked confused! And no, she didn’t tell him about the fenben. We are afraid he would drop her as a patient.We are so very grateful for fenben and how it’s helped her. She is feeling better, stronger, and enjoying her family. I have never posted on here. But I wanted to give you some hope!
**UPDATE**She had scans and bloodwork done 2 weeks ago and we got the results today!! She is eating better and gaining weight.. Her markers are now down to 6000. AND THE TUMORS ARE SHRINKING!!! We are very grateful!!
Read more: Fenbendazole and Pancreatic Cancer Success Stories
Discussion
The compiled case reports suggest fenbendazole (or mebendazole) and ivermectin may have significant therapeutic potential in stage 4 pancreatic cancer, including in chemotherapy-refractory cases. The rapid and profound tumor marker reductions and radiologic responses observed exceed typical outcomes with chemotherapy alone.
These findings align with mechanistic data demonstrating the ability of these agents to target multiple cancer hallmarks, including drug resistance and cancer stem cells.
In an (in silico) computer simulated randomised controlled trial (12), “Integrative Multimodal Therapy Incorporating Repurposed Antiparasitic Agents, Vitamin C, Pancreatic Enzymes, Berberine, and Metabolic Interventions” demonstrated a 72% 12-month overall survival rate versus 18% in the control arm (standard chemotherapy) for Non-BRCA-Mutated Stage 4 Pancreatic Cancer.
This simulated in silico RCT supports the potential efficacy and tolerability of a multimodal integrative approach combining repurposed anti-parasitic agents, nutrition, lifestyle interventions, and pancreatic enzyme supplementation for non-BRCA-mutated stage 4 PDAC.
However, limitations include the anecdotal nature of the evidence, lack of real world randomized controlled trials, and potential confounding from concurrent therapies. Reporting bias and placebo effects cannot be excluded.
Conclusion
Ivermectin and fenbendazole or mebendazole show promise as adjunctive therapies for advanced pancreatic cancer. Given the dismal prognosis of stage 4 PDAC (Pancreatic Ductal AdenoCarcinoma) and limited efficacy of current treatments, these agents warrant rigorous clinical investigation in controlled trials to establish safety, optimal dosing, and efficacy.
Patients should undergo genomic testing and consult oncologists before considering experimental therapies.
Conflicts of Interest: The authors declare no conflicts of interest.
References
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One Day MD 2025. Fenbendazole and Ivermectin for Pancreatic Cancer Success Stories: 29 Case Reports. https://www.onedaymd.com/2024/07/stage-4-pancreatic-cancer-fenbendazole.html.
The Cancer Advisor 2025. Advances and Emerging Therapies in the Management of Stage 4 Pancreatic Ductal Adenocarcinoma: A Comprehensive Review.
Pancreatic Cancer Survivor: Dr. Humberto M. Guiot (American Association for Cancer Research 2024)
New Research on cancer as a survival mechanism. The body is isolating the danger/poison, etc., and keeping it hostage away from killing the body…Yes these anti-parasitic drugs show promise in killing/removing the offending substance.
Where do I get my hands on it, I live in Norway and my sister is in stage 4.
Please help with legit source for ivermectin fenbendazol and methylene blue