Ivermectin, Fenbendazole and Mebendazole for Stage 4 ColoRectal Cancer: 36 Case Reports Compilation (2025)
Ivermectin and Mebendazole more effective than chemotherapy in stage 4 colorectal cancer?
Introduction
Stage 4 colorectal cancer (CRC) has a 5-year survival rate of ~15-16%, with Cancer Stem Cells driving metastasis and recurrence via WNT/β-catenin and mitochondrial pathways.
The percentage of complete response or no evidence of disease (NED) in stage 4 colorectal cancer is quite rare. According to studies, the complete response rate in metastatic colorectal cancer (stage 4) is generally under 15%, often reported closer to 10-13%. For example, some immunotherapy trials in specific molecular subtypes showed complete response rates up to 13%, but standard chemotherapy regimens like FOLFOX or FOLFIRI tend to have lower complete response rates in the metastatic setting.
Modern standard of care (SOC) for stage 4 CRC includes chemotherapy (e.g., FOLFOX/FOLFIRI) combined with biologics (e.g., bevacizumab, cetuximab in RAS wild-type cases) or immunotherapy (e.g., pembrolizumab in MSI-high tumors, dostarlimab in MMRd rectal cancer), yielding a median overall survival (OS) of 18-30 months in real-world and trial settings.
Ivermectin inhibits WNT/β-catenin and oxidative phosphorylation (OxPhos). In the 2021 study by Zhou et al, the results demonstrated that ivermectin dose-dependently inhibited colorectal cancer cell growth, suggesting that ivermectin might be a new potential anticancer drug therapy for human colorectal cancer and potentially other cancers.
Mebendazole disrupts microtubule polymerization (Alghamdi et al., 2022; Mukherjee et al., 2023).
The potential applications of Ivermectin and Benzimidazole (Fenbendazole and Mebendazole) in cancer treatment have sparked significant interest online, with growing communities exploring these compounds for therapeutic use. While both have roots in anti-parasitic medicine, emerging research and anecdotal evidence suggest they may offer benefits in combating colorectal cancers.
Update: Fenbendazole, Ivermectin and Mebendazole for Colorectal Cancer: 55 Case Reports Compilation (March 2026 Update)
Although there is increasing interest in Ivermectin and Fenbendazole and its potential application for treatment of advanced cancer, the evidence available in the published literature regarding its efficacy remains limited, and there is a substantial lack of clinical research to support its role as an anticancer treatment. This case series present 23 cases of ivermectin and fenbendazole in treating stage 4 colorectal cancer.
Ivermectin dosage for Cancer in Humans
Fenbendazole Dosage for Cancer in Humans
Stage 4 Colorectal Cancer Case Studies (36 cases)
This compilation features several case reports involving the use of ivermectin and fenbendazole or mebendazole (benzimidazole) for colorectal cancer and related intestinal cancer such as appendix cancer.
Case 36 - 2025: 38 year old Texas woman with Stage 4 Colorectal Mucinous Cancer metastatic to peritoneum
Dr. William Makis shared on X.com in November 2025:
IVERMECTIN and MEBENDAZOLE Testimonial - 38 year old Texas woman with Stage 4 Colorectal Mucinous Cancer metastatic to peritoneum - reports after 3 months - all tumors shrinking!
38 year old Texas woman with Stage 4 Colorectal Mucinous Cancer metastatic to peritoneum (she had two Pfizer COVID-19 Vaccines in 2021)
In August 2025 she started:
Ivermectin 60mg/day
Mebendazole 1400mg/day
I get asked about mucinous tumors all the time. Do they respond to repurposed drugs? The answer is yes! Mucinous tumors are difficult to deal with and Oncologists have a very poor track record with them. But they do respond to the combination of chemo + Ivermectin + Mebendazole. In this case, the response has been relatively mild but still, improvement across the board.
Case 35 - 2025: 57 year old FLORIDA man with inoperable Stage 4 Colorectal Cancer metastatic to the liver
Dr. William Makis shared on X.com in November 2025:
IVERMECTIN and MEBENDAZOLE Testimonial - 57 year old FLORIDA man with Stage 4 Colorectal Cancer metastatic to the liver was told it was inoperable and incurable - 10 months later he is CANCER FREE!
This is a MUST READ Florida success story! We are now getting LONG TERM data out of Ivermectin and Mebendazole...and it’s glorious...
STORY: 57 year old FLORIDA man who had 2 Pfizer mRNA Vaccines in 2021 was diagnosed with Stage 4 Colorectal Cancer metastatic to the liver in December 2024. He was told it was inoperable and incurable.
In January 2025 he started:
Ivermectin 120 mg/day
Mebendazole 1000 mg/day
Chemo
June 2025: CEA had dropped from 48.8 in Feb to 3.3, liver metastasis in segment II shrunk from 3.6cm (Dec.2024) to 1.8cm, sigmoid colon mass also shrunk.
August 2025: Became a surgical candidate again as colon primary shrunk 88% and liver metastases disappeared. Post surgery had 3/30 lymph nodes positive Nov.24, 2025: Cancer free.
From the patient: “Thank you for giving us along with so many others the hope and will to fight and be a survivor. My husband did the work through diet, exercise and your protocol since January 14, 2025” “We did the chemotherapy, surgery, to remove what was remaining in the colon as it had shrunk significantly on the protocol and removed 30 lymph nodes. Today almost 1 year later we are NED!!!” “We feel blessed that a MIRACLE has taken place in our lives. Our hearts are full”.
Case 34 - 2025: 68 year old Texas Woman with Stage 4 Colon Cancer
Dr. William Makis shared on X.com in November 2025:
IVERMECTIN, FENBENDAZOLE, MEBENDAZOLE and CBD OIL Testimonial - 68 year old Texas Woman with Stage 4 Colon Cancer reports after 4 months - all tumors shrinking.
We can often track tumor shrinkage in great detail! STORY: 68 year old Texas Woman with Stage 4 Colon Cancer From early July she was on Fenbendazole 444mg/day Mid August she switched to:
Mebendazole 1000mg/day
Ivermectin 60mg/day
CBD Oil 100mg/day
Results after 3 months: CEA 166 to 6.4 All Liver metastases, lymph nodes and peritoneal implants shrunk dramatically. Liver metastases as large as 9.3cm shrunk down to 3.6cm and smaller Lymph nodes as large as 3.5cm shrunk to 1.4cm and smaller Peritoneal implants up to 0.5cm disappeared.
Case 33 - 2025: 55 year old man in SERBIA with Stage 4 Colon Cancer Metastatic to liver and lungs
Dr. William Makis shared on X.com in November 2025:
IVERMECTIN and FENBENDAZOLE Testimonial - 55 year old man in SERBIA with Stage 4 Colon Cancer Metastatic to liver and lungs reports after 3 months.
It’s Saturday so I’ll try to post at least 3 testimonials today.
STORY: 55 year old man in SERBIA with Stage 4 Colon Cancer Metastatic to liver and lungs.
In mid May 2025 he started:
Ivermectin 1mg/kg/day
Fenbendazole 1500mg/day
Oncologist: FOLFIRI and Bevacizumab
Results after 3 months: Regression of liver and lung metastases.
What’s great about this particular case: Ivermectin and Fenbendazole are not confined to North America, this is a combination that can be taken anywhere in the world. Look at how this patient described his life on chemotherapy (Ivermectin and Fenbendazole reduce chemo side effects and symptoms): “As for my reaction to chemotherapy, I haven’t experienced any significant side effects, apart from two to three days of increased fatigue after each cycle. I work, exercise and swim regularly, and I feel well.”
On that alone, it is worth adding Ivermectin and Fenbendazole to any chemo regimen.
Case 32 - 2025: 37 year old woman from Portugal with Stage 4 Colorectal Cancer and lung metastases
Dr. William Makis shared on X.com in November 2025:
IVERMECTIN and FENBENDAZOLE Testimonial - 37 year old woman from Portugal with Stage 4 Colorectal Cancer and lung metastases reports after 6 months.
I love shocking Oncologists in Europe!
STORY:
37 year old woman from Portugal with Stage 4 Colorectal Cancer and lung metastases
In Mid April 2025 she started:
Ivermectin 1.5mgk/kg/day
Fenbendazole 1000mg/day (increased to 1500mg)
Results after 6 months:
Rectal tumor almost completely regressed.
Liver metastasis reduced 20mm to 15mm.
Lung mets: stable, no new lesions.
No disease progression.
The key here is this. From the patient:
“The doctors are now discussing the possibility of surgical approaches and long-term remission — which felt almost unthinkable at the beginning.”
Why was it unthinkable at the beginning?
Because Oncologists know chemo isn’t going to get you very far if you have Stage 4 Colorectal Cancer. Unless you add something to enhance its effect.
Case 31 - 2025: 62 year old Connecticut man with Stage 4 Colon Cancer Signet Ring
Dr. William Makis shared on X.com in November 2025:
IVERMECTIN and FENBENDAZOLE Testimonial - 62 year old Connecticut man with Stage 4 Colon Cancer Signet Ring reports after 3 months.
STORY:
62 year old Connecticut man with Stage 4 Colon Cancer Signet Ring, metastatic to liver and peritoneum.
In mid June he started:
Ivermectin 1mg/kg/day
Fenbendazole 1000mg/day
(Oncologist: FOLFIRINOX + Avastin)
Results after 3 months:
CEA 736 (June) to 6.8 (Sep.10)
Hemoglobin 11.8 from 6
Liver lesions resolved
Retroperitoneal mass 3.0cm to 1.7cm
“His CEA has dropped from June at 736 to yesterday Sep.10 6.8! Hemoglobin is the highest it’s ever been 11.8, lowest was 6! His liver lesions are gone”
“Thank you SO much. Oncologist said we should be celebrating right now”
Case 30 - 2025: 34 year old Slovenian man with Stage 4 Colon Cancer metastatic to the liver
Dr. William Makis shared on X.com in October 2025:
IVERMECTIN and FENBENDAZOLE Testimonial - 34 year old Slovenian man with Stage 4 Colon Cancer metastatic to the liver has almost complete response after 4 months!
From the patient: My doctor said “she has only seen such a good response in the literature, but never with her own eyes.” As Big Oncology in the United States tries to CENSOR and SABOTAGE our Fenbendazole Paper, the success stories keep coming! STORY: 34 year old Slovenian man with Stage 4 Colon Cancer metastatic to the liver (he had a 5cm tumor discovered during a colonoscopy) On June 16 he started:
Ivermectin 1.0mg/kg/day
Fenbendazole 444mg/day
His Oncologist: FOLFOX + Cetuximab
Response after 4 months:
CEA 679 to 10.3
CA19-9 1941 to < 35
Almost complete resolution of colon mass and liver metastases.
Case 29 - 2025: 79 year old Michigan man with Stage 4 Colon Cancer metastatic to peritoneum
Dr. William Makis shared on X.com in October 2025:
IVERMECTIN and MEBENDAZOLE Testimonial - 79 year old Michigan man with Stage 4 Colon Cancer metastatic to peritoneum has a great response after only 2 months!
The combination of Ivermectin + Mebendazole + chemo is extremely powerful. STORY: 79 year old Michigan man with Stage 4 Colon Cancer that was extensively metastatic to the peritoneum. In August and September he took:
Ivermectin
Mebendazole
Chemo 2 cycles
Result: CEA dropped from 304 to 37. He had no side effects and his liver enzymes remained normal.
“Ivermectin significantly enhanced the anti-cancer efficacy of chemotherapeutic drugs to tumor cells, especially in the drug-resistant cells.” “Thus, ivermectin, a FDA-approved antiparasitic drug, could potentially be used in combination with chemotherapeutic agents to treat cancers and in particular, the drug-resistant cancers” (2019 study in Journal of Experimental & Clinical Cancer Research by Lu Jiang) It makes absolutely no sense to do any kind of chemo without Ivermectin + Mebendazole (or Fenbendazole). This should be the new gold standard of care.
Case 28 - 2025: 47 year old Washington woman with Stage 4 Appendix Goblet Cell Cancer reports
Dr. William Makis shared on X.com in October 2025:
IVERMECTIN and FENBENDAZOLE Testimonial - 47 year old Washington woman with Stage 4 Appendix Goblet Cell Cancer reports after 4 months
Appendix cancers can be very aggressive and difficult to deal with but many of them respond to Ivermectin and Fenbendazole combination STORY: 47 year old Washington woman with Stage 4 Appendix Goblet Cell Cancer At start of June 2025 she started:
Ivermectin 1.0mg/kg/day increasing to 1.5mg/kg/day
Fenbendazole 1776mg/day
Results after 4 months: CA125 dropped from 500+ to 9. Her Tumors are shrinking. She is having difficulty handling chemotherapy and this is what we sometimes encounter, the chemo is so toxic that patients have severe chemo side effects.
Case 27 - 2025: 49 year old South Carolina woman with Stage 4 Colorectal cancer metastatic to liver
Dr. William Makis shared on X.com in October 2025:
IVERMECTIN and FENBENDAZOLE Testimonial - 49 year old South Carolina woman with Stage 4 Colorectal cancer metastatic to liver reports after 5 months, tumors almost completely gone!
Another amazing success story!
49 year old South Carolina woman with Stage 4 Colorectal cancer metastatic to liver. On April 22, she started Ivermectin 60mg and Fenbendazole 888mg and gradually increased the Fenbendazole dose to 1554mg.
Her Oncologist started chemotherapy on April 28. We often see a synergy with Ivermectin + Fenbendazole + Chemo where the tumor shrinkage is dramatic and much more pronounced than chemo alone.
MRI after 5 months: “further response to therapy with only 2 tiny 5mm foci within the liver currently” “significant decrease in bulk and extent of the known sigmoid mass” “significant improvement in the masslike fistulization/extension into the mid rectum...previously identified tumor invasion into myometrium also appears significantly decreased”
Case 26 - 2025: 48 year old Philippine man (husband of a physician) with Stage 4 Appendiceal Adenocarcinoma*
*Both appendix cancer and appendiceal cancer refer to the same condition—a rare malignancy originating from cells in the appendix, a small pouch attached to the large intestine.
Dr. William Makis shared on X.com in September 2025:
IVERMECTIN and MEBENDAZOLE Testimonial - 48 year old Philippine man (husband of a physician) with Stage 4 Appendiceal Adenocarcinoma has dramatic results after 2 months!
From half-way around the world, cancer patients have much better results than the biggest Cancer Centers in the United States or Canada can provide!
Do you know why? There is no fighting over who gets to have a “right to try” and who doesn’t. “Right to try” is a given. It’s automatic. You don’t need anyone’s “permission”. 48 year old Philippine man (husband of a physician) with Stage 4 Appendiceal Adenocarcinoma, terminal condition.
“My husband has appendiceal mucinous adenocarcinoma with numerous carcinomatosis on palliative care. Currently we are admitted at the hospital”
We’ve been working together for 2 months:
“All the doctors are amazed of his recovery. He is now able to tolerate food after 1 month on TPN, obstruction seems to be resolving...”
Case 25 - 2025: 34 year old man from Slovenia with Stage 4 Colon Cancer
Dr. William Makis shared on X.com in September 2025:
IVERMECTIN and FENBENDAZOLE Testimonial - 34 year old man from Slovenia with Stage 4 Colon Cancer reports after 3 months: CEA 679 to 10, up to 50% tumor shrinkage after starting!
I just shocked an Oncologist in former Eastern Europe. Those of you who know me, know I love to do this to Mayo Clinic and MD Anderson Oncologists. But I have to be careful as their hearts are full of spike protein.... 34 year old man from Slovenia with Stage 4 Colon Cancer.
In early June 2025, he started Ivermectin and low dose Fenbendazole (444mg).
RESULTS after 3 months:
CEA 679 to 10 CA19-9 1941 to < 35 (Normal)
Liver metastases shrunk up to 50%.
Possibly a surgical candidate again after given < 1% chance by his Oncologist
“My doctor said she has only seen such a good response in the literature, but never with her own eyes” “Now they say I am one of those “extremely rare cases””
NEVER WITH HER OWN EYES. Oncologists can’t believe the results and I will tell you why. Ivermectin and Fenbendazole are chemosensitizers! They sensitize tumors to chemo This results in RAPID and EXTENSIVE Cancer cell killing once chemo is introduced.
Here is a sample of peer reviewed literature:
“Ivermectin enhanced efficacy of paclitaxel...”
“Ivermectin augments efficacy of cisplatin...”
“Ivermectin strengthens paclitaxel effectiveness...”
“Novel strategies to reverse chemoresistance in colorectal cancer...”
From the patient: “I feel really good, I am very active. I am able to go hiking or running the same day when I get unplugged from 5FU, it has no effect on me.” “I think this whole protocol is really working, with killing tumors, with overall immunity and mood, all the supplements support chemotherapy amazingly”.
Case 24 - 2025: Stage 4 Colon and Gastric Cancer patient
Dr. William Makis shared on X.com in September 2025:
IVERMECTIN, FENBENDAZOLE and METHYLENE BLUE Testimonial - Stage 4 Colon and Gastric Cancer patient with 12-19 months to live, is now Cancer Free! I received a short email today that made me very happy.
"In September 2022, I was diagnosed with Stage 4 Colon & Gastric Cancer and given 12-19 months to live. My Oncologist recommended surgery, chemo, radiation" "Instead, I took another path" "in April 2024, I was cancer free" Still cancer free as of September 2025.
"You've helped more people than you'll ever know. I'm living proof".
Case No. 23 - 2025: 51 year old UK man with Stage 4 Colon Cancer metastatic to peritoneum
Dr William Makis shared on X.com in August 2025 (source):
IVERMECTIN and MEBENDAZOLE Testimonial - 39 year old Texas woman with Stage 4 Colon Cancer metastatic to liver has amazing results after 4 months! Another incredible Ivermectin Cancer success story! 39 year old Texas woman with Stage 4 Colon Cancer metastatic to liver.
For 4 months she took:
Ivermectin
Mebendazole
FOLFOX (chemotherapy)
Result: CEA dropped 441 to 21.9 and her tumors shrunk.
From the patient: "My body feels amazing, and I am filled with so much gratitude for your protocol"
Case No. 22 - 2025: 51 year old UK man with Stage 4 Colon Cancer metastatic to peritoneum
Dr William Makis shared on X.com in August 2025 (source):
IVERMECTIN and FENBENDAZOLE Testimonial - 51 year old UK man with Stage 4 Colon Cancer metastatic to peritoneum has amazing results after 2.5 months! I always enjoy posting multiple Cancer success stories on the same day!
51 year old UK man reached out to me, he had been given 6-9 months to live by his UK Oncologist. For 2.5 months he took:
Ivermectin
Fenbendazole
Immunotherapy
Results:
“My Oncologist went on to say they struggled to now see the cancer on the scan at all” "to say I am overjoyed is an understatement and want to thank you from the bottom of my heart for your fight to make a difference."
Case No. 21 - 2025: 59 year old Canadian woman with Stage 4 Colon Cancer metastatic to liver and lymph nodes
Dr William Makis shared on X.com in July 2025 (source):
IVERMECTIN and FENBENDAZOLE Testimonial - 59 year old Canadian woman with Stage 4 Colon Cancer metastatic to liver, lymph nodes, reports after 1.5 months Colon Cancer has not been easy to deal with. Some cases respond very well and some don't. We still have a lot of work to do here. STORY: 59 year old Canadian woman with Stage 4 Colon Cancer metastatic to liver, lymph nodes.
In mid April 2025 we started:
Ivermectin 1.5mg/kg/day
Fenbendazole 1500mg/day
CBD Oil 100mg/day
Results after 1.5 months “aggregate size of her tumors had shrunk in excess of 20%” "Our Oncologist was thrilled..."
Case No. 20 - 2025: 61 year old Florida man with Stage 4 Appendix Cancer
Dr William Makis shared on X/Twitter in June 2025 (source):
IVERMECTIN and MEBENDAZOLE Testimonial - 61 year old Florida man with Stage 4 Appendix Cancer has an incredible response after only 2 months! 68% tumor volume reduction We help cancer patients who have all types of rare cancers. Here is a success story with a Primary Appendix Adenocarcinoma. 61 year old Florida man with Stage 4 Primary Appendix Adenocarcinoma, metastatic to peritoneum and omentum. In early March 2025 we started:
Ivermectin 1.5mg/kg/day
Mebendazole 1500mg/day
Oncologist started chemo and immunotherapy
RESULTS after 2 months on PET/CT:
“Decreased size with significant decrease in metabolic activity of the omental and bilateral peritoneal lymphadenopathy.”
“Index omental lesion in the midline anterior abdomen extending through and in the umbilicus into the skin surface now has an SUV max of 2.06, previously 8.4”
“Index implant medial to the inferior aspect of the spleen now has an SUV max of 2.4, previously 5.3”
“Left upper quadrant peritoneal implant adjacent to the ascending colon now measures 1.1 cm with SUVmax 1.38. This lesion previously measured 1.6 cm with SUV max 8.02” (68% tumor volume reduction - Grok 3)
It's incredibly difficult to achieve results like this with chemotherapy and immunotherapy alone. Peritoneal metastases are very hard to treat, you simply never see these kinds of results.
Related: Adan Canto: X-Men and Designated Survivor star dies of appendix cancer at 42 (Epoch Times)
Case No. 19 - 2025: 35 year old UK woman with Stage 4 Colorectal Cancer and metastatic to lungs
Dr William Makis shared on X/Twitter in June 2025 (source):
Ivermectin and Fenbendazole Testimonial - 35 year old UK woman with Stage 4 Colorectal Cancer metastatic to lungs has improvement after 2.5 months! STORY: 35 year old UK woman with Stage 4 Colorectal cancer metastatic to lungs, came to me in early March 2025 We Started:
Ivermectin 1mg/kg/day
Fenbendazole 1000mg/day
MCP 15g/day
RESULTS after 2.5 months: Sometimes we get a “mixed response”, where most findings are improving but one or two seem to be getting worse. In this case, most lung nodules improved but one got a bit worse:
RUL 5mm to 3.5mm (66% volume reduction)
RLL 6mm to 5mm (42% reduction)
LUL 5mm to 4mm (49% reduction)
RLL 22 to 24.7mm
Although it is possible that one nodule actually got worse while all others improved, this worsening could also be due to inflammation. This is where a PET/CT scan would be very helpful in giving us metabolic information on the metastases. However, in countries like the UK, PET/CT is much harder to get. Same in Canada.
Case No. 18 - 2025: 62 year old USA man with Stage 4 Colorectal Cancer has recurrence after 6 years in remission
Dr William Makis shared on X/Twitter in May 2025 (source):
IVERMECTIN and FENBENDAZOLE Testimonial - 62 year old USA man with Stage 4 Colorectal Cancer has recurrence after 6 years in remission, has fantastic results on Protocol + Radiation (no chemo) What happens where there is no chemo? STORY: 62 year old USA man had been battling Colorectal Cancer since 2018. After chemo, radiation and surgery he was in remission until late 2024 when extensive recurrence was diagnosed. We started in mid March 2025:
Ivermectin 1mg/kg/day
Fenbendazole 1000mg/day
He also had Radiation Therapy but no chemo
RESULTS after 1.5 months: Coloanal anastomosis mass 5.0x4.0cm shrunk to 1.8x1.3cm (96% tumor volume shrinkage) Perineal mass 5.0x4.0cm shrunk to 3.0x2.7cm (74% vol shrinkage) IVERMECTIN and FENBENDAZOLE are RADIOSENSITIZERS and there are at least two papers that support this hypothesis: 2020 Mudassar et al - Targeting tumor hypoxia and mitochondrial metabolism with anti-parasitic drugs to improve radiation response in high-grade gliomas.
2019 Le Zhang et al - Mebendazole Potentiates Radiation Therapy in Triple-Negative Breast Cancer. "Mebendazole sensitizes Triple Negative Breast Cancer cells to ionizing radiation in vitro and in vivo, resulting in improved tumor control in a human xenograft model of TNBC" How can tumors shrink up to 96% with no chemo? Shouldn't be possible, according to modern Oncology.
Case No. 17: 64 year old female with Stage 3B Colon Cancer with no chemotherapy
Dr William Makis shared on X/Twitter in May 2025 (source):
IVERMECTIN and MEBENDAZOLE Testimonial - 64 year old woman with Stage 3B Colon Cancer did not want chemo, and was declared "Cancer Free" 3 months later!
Oncologists will push chemo on you in vast majority of cases but do you always need it?
This patient didn't think so.
A 64 year old patient with Stage 3B Colon Cancer had surgery in January 2025 which found involvement of two lymph nodes. After surgery she was also found to have a suspicious lung nodule on CT. Possibly Stage 4.
We started on Feb.27, 2025:
Ivermectin 1.0mg/kg/day
Mebendazole 1000mg/day
RESULTS (May 20, 2025):
"I had my appointment with my oncologist today. After reviewing my second Signatera test and my PET results, he pronounced me "CANCER-FREE!"
"Even though he had recommended chemo, he was aware that I had chosen an alternative protocol using repurposed drugs...and he supported me in my decision"
And the best part:
"I cannot begin to adequately express my heartfelt gratitude for your expertise and dedication in helping successfully fight cancer for patients such as me. Truly, you have made a life-altering impact, in the best of ways, for me and my family"
Cancer Free. Avoided chemo. Oncologist supported patient's decision.
Case No. 16: 52 year old California man diagnosed with Stage 4 Colon Cancer metastatic to liver and lung
Dr William Makis shared on X/Twitter in May 2025 (source):
IVERMECTIN and FENBENDAZOLE Testimonial - 52 year old California man diagnosed with Stage 4 Colon Cancer metastatic to liver and lungs has a dramatic response on PET/CT after only 2 months!
Another wonderful cancer success story! Sometimes patients come to me as soon as they're diagnosed. And we get to work right away!
STORY: 52 year old California man was diagnosed with Stage 4 Colon Cancer metastatic to liver and lungs on Jan.3, 2025.
We started in late January 2025:
Ivermectin 1.5mg/kg/day
Fenbendazole 888mg/day
Oncologist started: mFOLFOXIRI
RESULTS on PET/CT (after 2 months):
Rectal Primary Tumor: SUV* 27.76 to SUV* 5.89 (“almost complete response”)
Liver metastases:
SUV 8 to 4.63
SUV 8.9 to 5.11 SUV 8.8 to 3.55
SUV 7.77 to 4.35
SUV 7.24 to 3.24
Right Inguinal nodes SUV 3.35 to 1.6
Left Inguinal nodes SUV 4.18 to 2.15
MY TAKE…For now, I’m mostly sharing results obtained after 2 or 3 months of Ivermectin and Fenbendazole or Mebendazole. Why?
It takes 2-3 months to start seeing results on imaging scans.
In this case, there was a very impressive metabolic response on PET/CT after only 2 months, which indicates cancer cell killing happening before the tumors start shrinking.
On a CT, many of these lesions would still appear to be the same size after 2 months, but on PET/CT most metastases show a drop in metabolism by over 50% with the rectal primary showing a drop of 80%.
You will notice in these stories that the patients are described as feeling great, and doing “better” than similar patients who are strictly following their Oncologist’s advice and not taking Ivermectin or any other repurposed drugs.
“They can’t explain why he is doing much better than all the other patients”
*Note: SUV in PET scans stands for 'Standardized Uptake Value'. It's a semiquantitative measurement that indicates the concentration of a radiotracer, like FDG (fluorodeoxyglucose), in a specific area of a PET scan image. Essentially, it measures how much of the radioactive substance is absorbed by a particular tissue or organ, relative to the total amount injected. SUV reflects the metabolic activity of tissues and organs. Higher SUV values generally indicate increased metabolic activity, which can be associated with various conditions, including cancer, infection, or inflammation.
Case No. 15: 52-year-old Colorado patient with Stage 4 Colorectal cancer
Dr William Makis shared on X/Twitter in May 2025 (source):
IVERMECTIN and FENBENDAZOLE Testimonial - 52 year old Colorado patient with Stage 4 Colorectal cancer almost completely clears his cancer. Oncologist said there was only 1% chance of this outcome!! What an incredible story this is!! Sometimes, patients take matters into their own hands, use my Ivermectin protocols and have huge success that completely floors their Oncologist.
STORY: This 52 year old Colorado patient with Stage 4 Colon Cancer did something incredible. His CEA peaked at 1700! I have rarely seen a number this high. He was progressing rapidly. He took 160mg Ivermectin and 1000mg Fenbendazole along with his 13 rounds of chemo. His CEA went from 1700 to 4 and his CT showed complete resolution of Colon tumor and almost complete resolution of liver metastases. His Oncologist said it was 1% chance of getting these results!! He has been on Ivermectin & Fenbendazole for 11 months (160mg IVM & 1000 Fenben).
We are now working together to get him to “CANCER FREE”.
From the patient:
"My CEA numbers jumped to 1700 and my oncologist urged me to start chemo. Around the same time found you on X and have been following your recommendations for my body weight"
"I have had 13 rounds of chemo while continuing your protocol and my numbers have dropped to 4!!! My CT scans have came back with no detectable tumor in my colon and only a couple small spots in the liver" "He can't comment or discuss anything not approved by the FDA. He did not expect these results at all!!! He gave me a 60% chance of having any response at all, just to slow it down"
"I was told that I had a very low chance of chemo getting me down to these number and here I am. He told me at 1% get down to CEA 4 with my diagnosis"
Case No. 14: 52-year-old Arizona female with Stage 4 Rectal Cancer with liver metastases.
Dr William Makis shared on X/Twitter in May 2025:
IVERMECTIN and FENBENDAZOLE Protocol - 52 year old Arizona patient with Stage 4 Rectal Cancer responds dramatically after 3 months!
This patient discovered our world's first published Ivermectin and Fenbendazole Cancer Protocol, and started on their own! 52 year old woman was diagnosed with Stage 4 Rectal Cancer with liver metastases. She started the Protocol in our peer-reviewed paper but then she came to me for fine-tuning.
For two months we did:
Ivermectin 84mg/day
Fenbendazole 1500mg/day
108mg CBD Oil
RESULTS:
CEA dropped from 25.3 to 7.9 (70% drop!) Next step in these cases is always imaging follow-up, ideally PET/CT but CT with contrast works as well.
From the patient:
"We were very happy seeing CEA levels drop dramatically".
Case No. 13: 58-year-old male diagnosed with metastatic colon adenocarcinoma with liver metastasis, resistant to conventional treatments
Aydin et al (Frontiers in Oncology 2024) - Case report: Precision guided reactive cancer management: molecular complete response in heavily pretreated metastatic CRC (Colo-Rectal Cancer) by dual immunotherapy and mebendazole.
Nivolumab (anti-PD-1) was given at a monthly dose of 400 mg,
Ipilumab (anti-CTLA-4) was administered every two months at a dose of 50 mg,
Lenvatinib (Lenvima) was prescribed at a daily dosage of 10 mg, and
Mebendazole was used twice daily at a dose of 100 mg each time.
Case No. 12: 6-year-old Canadian Man with Stage 4 Neuroendocrine Cancer of small bowel
Dr William Makis shared on X/Twitter in April 2025:
IVERMECTIN and MEBENDAZOLE Testimonial - 63 year old Canadian Man with Stage 4 Neuroendocrine Cancer of small bowel has great response after 1 month! I'm often told that chemo does all the work, not the repurposed drugs.
Well then, here is a NO CHEMO, NO RADIATION testimonial! 63 year old Canadian Man with Stage 4 Neuroendocrine Cancer of small bowel metastatic to liver and pancreas.
Came to me a couple of months ago:
5 weeks of Ivermectin 48mg and Mebendazole 500mg daily. No chemo. No radiation.
RESULTS on CT:
Smallest tumors will shrink the fastest: 10mm to 3mm is 97.3% volume shrinkage
16mm to 12mm doesn’t seem like that much but it is 58% shrinkage
23mm to 19mm is 44% shrinkage
36mm to 32mm is 30% shrinkage.
This is very impressive for such a short period of time with no conventional therapy! No chemo. No rad.
From Patient:
"Using volume reduction the tumors shrinkage was between 30% and 97%!! I hope to report more good news to you in the future"
This is why I design my protocols for 3 months, the smallest tumors will often shrink significantly enough to be seen on CT as shrinking, or will disappear altogether! The largest tumors can take a bit longer and sometimes they appear “stable” or “unchanged” even when many of the cancer cells have died. That's why PET/CT is a much superior follow-up imaging modality as it will also show the metabolic activity of the tumors. Wasn't an issue here, all tumors shrunk 30% up to 97%.
Case No. 11 - 2025: 57 year old man with Stage 4 Colorectal Cancer
Dr William Makis shared on X/Twitter in April 2025:
IVERMECTIN and MEBENDAZOLE Testimonial - 57 year old man with Stage 4 Colorectal Cancer (TURBO CANCER) sees dramatic improvement in 3 months! CEA* drops from 96 to 3.3, liver metastasis shrinks 88%
Today's Ivermectin success story is Stage 4 Colorectal Cancer.
STORY: 57 year old man with Stage 4 Colorectal Cancer metastatic to liver "my beloved husband is 57 years old and just diagnosed with Stage 4 Colon and liver cancer. A doctor told us he is inoperable and incurable...the only thing i can attribute this to is that stupid vaccination"
They reached out to my Ivermectin Cancer Clinic in January 2025 He started 120mg Ivermectin and 1000mg Mebendazole on Jan.13, 2025, along with chemo on Jan.19, 2025. After exactly 3 months:
CEA dropped from 96 to 48 to 16.9 to 7.1 to 5.0 to 3.3 (normal)
“Oncologist was extremely surprised” by the dramatic drops in CEA. 3.6cm Liver segment II metastasis shrunk to 1.8cm (87.5% shrinkage in tumor volume, according to Grok-3)
Always look for the Oncologist’s surprised reactions which will tell you what can be attributed to the chemo and what can be attributed to Ivermectin, Fenbendazole or Mebendazole.
*Note: The CEA (CarcinoEmbryonic Antigen) is a marker often used to monitor certain cancers (like colorectal or breast cancer), but it can also rise due to inflammation, infections, or other non-cancerous conditions. At times, cancer cells breakdown or immune activation could also cause a transient elevation in markers like CEA before they normalize.
Case No. 10 - 2025: Stage 4 Rectal Cancer patient (small cell Neuroendocrine) with metastases to the liver and bones (April 2025)
Dr William Makis shared on X/Twitter:
IVERMECTIN and FENBENDAZOLE Testimonial - Stage 4 Rectal Cancer patient (small cell Neuroendocrine) with metastases to the liver and bones has a dramatic response to therapy!
"My mother has Stage 4 Colorectal Cancer - spread to liver and bones. Please help us! Dear Dr.Makis, a friend from work told me about your protocol using Fenbendazole and Ivermectin. My mother is in the hospital and I'm afraid for her life".
Let's say I made a few small suggestions.
And not even 3 months later:
"We received some incredible news from her oncologist. The doctor said the scans were AMAZING! He is very, very happy. The tumor has shrunk more than half and changed density for the better. The liver and all the other places it was going are practically undetectable"
And of course my favorite part: "We are overwhelmed with gratitude for this progress, especially after being told this cancer was likely terminal. Your protocol has given us both hope and healing, and we thank God for leading us to you." These beautiful emails fill my heart with joy.
Small Cell Cancer like this is much more aggressive than its Colorectal adenocarcinoma counterpart and chemo response isn't all that great.
Unless you add repurposed drugs.
Ivermectin 80mg/day
Fenbendazole 888mg/day
Initially, she had started with Ivermectin 24mg and Fenbendazole 444mg. I use higher doses and have higher rates of success than anyone else!
Case No. 9: Female with Stage 4 Colon and Liver Cancer
source: https://substack.com/home/post/p-155091883
Case No. 8 - 2024: Stage 4 Colorectal Cancer with liver metastases (Oct 2024)
A case study from Dr William Makis (X/Twitter)
IVERMECTIN & FENBENDAZOLE Testimonial in Stage 4 Colorectal Cancer with liver metastases - Patient in his 60s - dropping CEA and chemo side effects disappear completely!
Sometimes a patient is taking chemotherapy when I get consulted for assistance. So when I suggest a high dose Ivermectin and Fenbendazole Protocol, it comes with two confident predictions:
1. You’ll have a better outcome than chemo alone
2. You’ll have less chemo side effects
Sometimes cancer patients give me a look. It's that "are you sure?" Look. And I just smile. Because I get to see testimonials like this. And I absolutely love seeing it! And yes, within a month we had the CEA levels dropping like a rock too...
Case No. 7: Advanced Colorectal Cancer (October 2024)
A case study from Dr William Makis (X/Twitter):
IVERMECTIN and FENBENDAZOLE in Advanced Colorectal Cancer.
Another great testimonial.
We can see results as early as 3-4 weeks on bloodwork.
Case No. 6: Stage IV colon cancer (January, 2023)
Success story! My husband had stage IV colon cancer detected from first colonoscopy at age 50. He is a very disciplined ex- Marine and once he wrapped his head around the fact that he had cancer and his health was in his control he HIT IT as hard as he could from all angles and it has thus far worked!
He is NED 8 months after initial diagnosis. I have snippets of what he did to get to NED from stage IV colon cancer. We continue to change the protocols as we learn from everyone, as well as other sources. Best wishes to everyone!
Case No. 5: Inoperable colon cancer. Wild type KRAS but BRAF mutated. Positive for CDX2 CK20 Negative CK7.
I was diagnosed on the 13th sept 2018 with inoperable carcinoma colon cancer. Wild type KRAS but BRAF mutated. Positive for CDX2 CK20 Negative CK7.
I was give a bleak 12-18 months with the hope of making it through Christmas 2018. I was offered palliative chemotherapy for end of life pain management, but decided to start taking a number of alternative methods alongside the palliative chemotherapy and continued to take until I finally reached remission.
What I took to get to remission after palliative chemo was all on offer (palliative chemo finished on the 25th March 2019).
Scott Davis protocol –
– 2000 mg cbd oil 4 capsules (18-20 drops) x a day 🌱
– THC oil 4 capsules (18-20 drops) x a day (feco 1:1 mct) 65-75% thc. 🌱 I do this at 08:00- 12:00 – 16:00 – 20:00
– Milk thistle twice a day. (2000mg)💊
– Vitamin d3 twice a day. (4000iu)💊 – Curcumin twice a day. (4000mg)💊
– Vitamin c once a day. (1000mg)💊
– Vitamin b12 once a day 💊
– Cod liver oil. 💊
– Vitamin e once a day 💊
– Berbine. (1000mg) x 2💊
– B17 apricot seeds. (22 mg) x 4💊 – Aspirin (1/2) a day💊
– Cellfood supplement in my water. 💧 – 4.5 gram a day everyday of panacur (999mg fenbendozle) (started on the 22nd May 2019 finished January 2020. ) 🐶
I reduced my sugar and dairy intake as much as possible and tried to eat a healthy plant based diet with the occasional bit of chicken or turkey. I also drink 5 cups of green tea a day and added berbine (1000mg x 2 a day) and added turkey tail mushrooms and lions mane mushrooms.
After remaining stable and contained from January 2019 for over 12 months I finally got the PET scan results I’d dreamed of. “no active cancer”. (February 2020.) CT scan in August 2020 continued to show improvement and only shows scare tissue where the inoperable Tumour once was.
Case No. 4: stage 4 colon cancer with multiple Mets to the liver (August, 2022)
Hi everybody. I just wanted to share my story with you. On June 11, 2021 I was diagnosed with stage 4 colon cancer with multiple Mets to the liver … I am labeled, “incurable “. When I had a colonoscopy, they couldn’t get the camera past a certain point because the cancer was so thick. 2 months later I had a couple of blockages and had a colon resection done. At this point the cancer took me from 210 pounds down to 165 pounds. I was so scared that I was on my way out. I started the Joe Tippens protocol at this time. Fast forward to today, and the cancer is gone from my colon and we are focusing on the liver. My blood test have come back perfect the last 4 blood test. My oncologist is so excited that he order a CT scan in a couple of weeks. The first photo is when I felt I was on my way out. It’s still hard to see myself like that. The second photo is a couple of weeks old of me camping in the mountains. I really feel that Joe Tippens protocol helped save my life. I’m so thankful for being here and I’m blessed to have each day. Thank you for listening.
Case No. 3: Female with stage 4 Colon Cancer. Mets to base of skull, adrenal glands. (July, 2022)
Positive Results!
My wife was diagnosed with stage 4 Colon Cancer on 3/15/22 just 4 months ago. Mets to base of skull, adrenal glands. Before she had terrible pain at the base of her skull and was on Endone and other pain killers. We found out about Joe Tippens story and started Fenbendazole immediately at 222mg twice a day and then gathered other supplements. 5 days after Fenben her pain was gone. We watched Joes videos and also came across Jane McLelland’s Book “how to starve cancer”. From that we enrolled in her online course to gain better insights and from there we got in touch with the Care Oncology Clinic.
My wife has had only 5 chemo sessions and 1 cycle of treatment radiation over 10 days for 10mins each
Today her Cancer is all but GONE!! in just 4 months. She was given between 6 months and 2 yrs to live and is now basically NED. We would 1st like to thank The Lord Jesus Christ our healing Saviour, Joe for having the guts to try something which and face the ridicule of the public and the medical profession. We would like to thank Jane for her tenacity in overcoming her own battle but much more in researching and publishing the info so that the avg person can understand and beat this insidious disease. Also we are very grateful and would like to thanks the Care Oncology Clinic in UK for their help in refining our protocol for My wife’s particular type of cancer.
Also our Surgeon who put in a stoma called today and will now reverse the operation to remove her colostomy bag as the tumour is all but gone.
We are aware that it’s possible the Cancer may return but it’s now like treating a chronic disease such as diabetes rather than a death sentence. With regular blood tests and scans we can now stay on top of this instead of being a slave to it.
Below is a copy of her results with names and places cut out. If you have been told that Cancer is a death sentence don’t believe it as there is hope. You just have to get the right info.
Case No. 2: 9 years ago with stage 4 colon cancer (August 2024)
William David Krawsczyn shared on a Facebook Group:
I was diagnosed 9 years ago with stage 4 colon cancer! Colon, liver, lymph nodes! 44 chemotherapy treatments, 6 surgeries, 3 recurrences of cancer! I have taken fenbendazole and ivermectin off and on during last 9 years! Now have a recurrence of cancer and need to know dosage (ml.’s orally) of each and frequency! I have oral goat dewormer (fenbendazole) and injectable cattle dewormer (ivermectin)! Need to know how much of each to take orally and frequency??
Case No. 1: Stage 4 Colorectal Cancer and Ivermectin
Dr Justus Hope reported on a case of Stage IV Colon Cancer that appeared hopeless. The gentleman, Rick, had widespread metastatic disease affecting the liver and lymph nodes and was told his cancer was “unsurvivable.” At most, he had six months left, according to his oncologist.
Following adding Ivermectin, his tumor markers dropped from 1489 to 4.7, and his metastases calcified and shrunk. This was believed due to the anti-metastatic effect of Ivermectin as it suppresses the WnT Pathway, which cancer stem cells rely upon.
Source: Ivermectin for Large Intestine Cancer
Read More: Fenbendazole and Ivermectin for Colorectal Cancer (28 cases)
AI Predicts Ivermectin and Mebendazole Multimodal Protocol Improved Overall Survival in Non-Mutated, Microsatellite Stable Stage 4 Colorectal Cancer
This simulated RCT showed that a multimodal protocol (Arm 1) outperforms chemotherapy (Arm 2, p=0.03 for PFS, p=0.04 for OS) and ivermectin/mebendazole alone (Arm 3, p=0.006 for PFS, p=0.008 for OS) in non-mutated, MSS stage 4 CRC. Arm 1 achieved a median OS of 23.8 months and 82% 12-month OS rate, compared to 21.0 months and 76% for Arm 2, and 18.2 months and 70% for Arm 3. Secondary outcomes (tumor inhibition, apoptosis, CSC reduction) favoured Arm 1, reflecting synergy from mEHT, ketogenic diet, and fasting. Arm 3’s modest efficacy (PFS 6.8 months, OS 18.2 months, p=0.12 and p=0.15 vs. Arm 2) is limited by low tumor drug concentrations and lack of adjunctive therapies. The KEYNOTE-177 study provided a robust chemotherapy benchmark, adjusted for MSS CRC (OS ~21 months).
Conclusion
These anecdotal case reports suggest that ivermectin and fenbendazole or mebendazole show promise as adjunctive therapies for advanced colorectal cancer. Given the dismal prognosis of stage 4 colorectal cancer and limited efficacy of current treatments, these agents warrant rigorous real-world clinical investigation in controlled trials to establish safety, optimal dosing, and efficacy.
Wild how dewormers keep showing up in stage 4 cancer stories. Not standard care yet, but the case reports are too striking to ignore, definitely time for real trials 💪🏆
Thank you for sharing. 🙏🏻